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Does Ozempic Make You Tired?

Published: Mar 11, 2025
Updated: Mar 11, 2025
Does Ozempic Make You Tired?
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    9 min

    Ozempic is an injectable medication that has been a popular topic on social media platforms like TikTok. Besides being a medication for type 2 diabetes, many people including famous celebrities have decided to take it for weight loss. However, one common question among users is: Does Ozempic make you tired? While Ozempic helps regulate blood sugar and support weight loss, some individuals have reported experiencing fatigue as a side effect.

    In this article, we’ll discuss why ozempic may be making you feel tired and ways to manage this fatigue.

    Key Takeaways
    Ozempic is a semaglutide injectable prescription medication used to help those with type 2 diabetes maintain their blood sugar levels.
    Common side effects of Ozempic include nausea, diarrhea, and vomiting.
    While some people have reported facing sleep disruptions, there is no proper research that directly links ozempic to insomnia.
    Getting more consistent and quality rest can help to combat ozempic-related fatigue.
    A high-nutrient diet, regular exercise, staying hydrated, and monitoring your blood sugar levels closely may also be beneficial.

    What is Ozempic?

     A person holding on to Ozempic semaglutide injection.

    Ozempic is a weekly injectable prescription medication that is used to manage and improve blood sugar levels in adults with type 2 diabetes. It can also be used to reduce food cravings, increase insulin production, and lower the risk of heart attack, or death in patients with type 2 diabetes and a known heart disease [1], [2].

    How does ozempic work?

    Ozempic contains an active ingredient known as semaglutide or GLP-1. This natural compound is released from your gastrointestinal tract once you consume a meal, stimulating insulin secretion. It also inhibits glucagon release, slowing gastric emptying such that the rate of glucose circulating is reduced [3].

    Ozempic can also help to terminate food intake signals in the brain, curbing appetite and aiding weight loss [4].

    Common side effects

    Some individuals may experience side effects when it comes to taking ozempic. The most common side effects of ozempic include [5]:

    • Nausea
    • Stomach pain
    • Constipation
    • Diarrhea
    • Vomiting

    Ozempic may also cause possible serious side effects such as:

    • Pancreatitis
    • Changes in vision
    • Low blood sugar
    • Dehydration
    • Allergic reactions
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    Why Does Ozempic Make You Tired?

    Illustration of a person appearing fatigued, reflecting the tiredness linked to Ozempic use shuteye app

    Currently, there is still a lack of research as to why Ozempic may cause fatigue. However, some possible explanations include:

    • Reduced calorie intake: As the medication helps to reduce appetite, it may result in a lower calorie intake. This not only leads to weight loss, but it can also lead to fatigue if it’s significantly lower than what the body is used to.
    • Low blood sugar levels: Low blood sugar is a possible side effect of ozempic and can cause tiredness.
    • Gastrointestinal issues: One of the commonly reported side effects is related to gastrointestinal side effects such as nausea and vomiting during the initial weeks. These can be energy-draining, leading to fatigue.
    • Metabolic adjustments: When starting ozempic, your body needs time to adjust. During this period, you may experience temporary fatigue.

    Does Ozempic Affect Sleep Pattern?

    Sleep problems like insomnia are not a known side effect of ozempic. However, some may experience sleeplessness while taking the medication. A study that was done analyzed comments and videos that were posted on social media related to the use of GLP-1 receptor agonists and found some of them linked to insomnia and sleep issues.

    However, as this study is not well-controlled, it is hard to confirm whether GLP-1 receptor agonists such as ozempic are a direct cause of insomnia. Experts suggest that these sleep issues may be linked to factors such as gastrointestinal discomfort, blood sugar fluctuations, or the medication’s influence on hormones that regulate alertness [6], [7].

    Ways to Manage Ozempic Fatigue

    If you’re experiencing fatigue while taking ozempic, here are some ways to help you manage it:

    Get more rest

    A woman peacefully getting more rest in bed, her arm stretched out comfortably beside her.

    Quality sleep plays a crucial role in overall health, particularly for those managing diabetes or using medications like Ozempic. Lack of sleep can disrupt hormone regulation, increase stress levels, and impact insulin sensitivity. To improve rest, establish a consistent sleep schedule by going to bed and waking up at the same time each day.

    Additionally, you may create a relaxing bedtime routine by limiting screen time, reducing caffeine intake in the evening, and engaging in calming activities such as reading or meditation. Maintaining a comfortable sleep environment is also important to further enhance sleep quality.

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    Focus on good nutrition

    A woman at a table with a phone and a bowl of food, enjoying her meal while using her phone.

    A balanced diet is essential for maintaining energy levels, supporting metabolic health, and managing blood sugar. Prioritize nutrient-dense foods, such as lean proteins, whole grains, healthy fats, and fiber-rich vegetables, to promote satiety and stabilize blood sugar levels.

    If you experience digestive discomfort while taking Ozempic, try eating smaller, more frequent meals to ease digestion. Consulting a registered dietitian can also help in creating a meal plan that aligns with your health goals.

    Exercise regularly

    Regular physical activity is beneficial for weight management, cardiovascular health, and blood sugar control. Engaging in moderate-intensity exercises, such as walking, swimming, or cycling, for at least 150 minutes per week can help improve insulin sensitivity and overall well-being.

    If you are new to exercise or experiencing fatigue from medication, start with low-impact activities and gradually increase intensity.

    Monitor blood sugar levels

    A woman uses a blood glucose meter to monitor her blood sugar levels effectively.

    Keeping track of blood sugar levels is essential for individuals managing diabetes or using glucose-regulating medications. Regular monitoring helps identify patterns and allows for timely diet, exercise, and medication adjustments. Aim to check blood sugar consistently, such as before meals and bedtime, to get an accurate picture of how your body responds throughout the day.

    Conclusion

    Although Ozempic may be an effective medication for those with type 2 diabetes and for those looking to lose weight, it’s important to note that fatigue can be a possible side effect for some people. Additionally, factors such as reduced calorie intake, blood sugar fluctuations, and metabolic adjustment could further contribute to this tiredness.

    One way to avoid fatigue and improve your sleep quality naturally is by using the ShutEye® app. Our app offers personalized sleep-tracking insights, relaxing sounds, and expert sleep tips to improve your sleep. Try ShutEye® for FREE today!

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    FAQ

    The duration of fatigue may differ for every individual as several factors can influence it. Generally, it could take anywhere between 1 week to 12 weeks to adjust to semaglutide and not feel tired.

    While on ozempic, it's important to prioritize consuming a balanced diet, staying hydrated, and getting enough quality rest.

    If you have type 2 diabetes, you should avoid eating sugary foods or drinks as foods or drinks with high glycemic index may make it harder to control your blood sugar levels and counteract the effects of ozempic.
    About authors
    Amirah is a content writer passionate about topics related to mental health and wellness. Recently, she delved into the realm of sleep health, spurred by a personal recognition of her subpar sleep habits and a desire for improvement. Amirah holds a Bachelor’s Degree in International Communication Studies from the University of Nottingham.

    Beabout, L. (2024) Does Ozempic cause insomnia? [online]. Available at: https://www.singlecare.com/blog/does-ozempic-cause-insomnia/

    Health Hub (2024) Semaglutide Injection (Ozempic®) [online]. Available at: https://www.healthhub.sg/a-z/medications/semaglutide-injection-ozempic

    Novo Nordisk (2024) Possible Side Effects of Ozempic® (semaglutide) Injection [online]. Available at: https://www.ozempic.com/how-to-take/side-effects.html

    Novo Nordisk (2025) What Is Ozempic® (semaglutide) Injection? [online]. Available at: https://www.ozempic.com/why-ozempic/what-is-ozempic.html

    Novo Nordisk (2025) Once-weekly Ozempic® (semaglutide) injection mechanism of action [online]. Available at: https://www.novomedlink.com/diabetes/products/treatments/ozempic/about/mechanism-of-action.html

    Sleepopolis (2024) Can Ozempic Impact Sleep? Social Media Study Finds Theme of Ozempic-Related Sleep Issues [online]. Available at: https://sleepopolis.com/news/ozempic-sleep-related-issues-on-the-rise/

    Touchstone, L. (2024) How do drugs like Ozempic work for weight loss? [online]. Available at: https://mcb.illinois.edu/news/2024-07-09/how-do-drugs-ozempic-work-weight-loss

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